Native mass spectrometry is a technique used to analyze intact proteins and protein complexes without denaturing or modifying them. It allows for the measurement of the molecular weight of proteins and their interactions with ligands or other proteins in their native state. This technique has been widely used in structural biology and drug discovery research, as it provides valuable information about protein structure, function, and dynamics in their native conformations. Native mass spectrometry is also a powerful tool in biomolecular interaction studies and can provide insights into protein-protein interactions, protein-ligand binding, and protein conformational changes.